Vince Vaughn may have been a winner at a Cinco de Mayo poker event, though not necessarily at cards. Vaughn left the party with a young blonde.

While Jen Aniston has been canoodling on a Miami beach with John Mayer, Vaughn celebrated Cinco de Mayo at the Velvet Margarita party in Hollywood Monday night.

The comedian showed up to the cantina around 10 p.m. for a charity poker tournament with a couple members of his Wild West Comedy Tour. The buy-in was $120, with all proceeds going to the charity Friends of El Faro, which donates money to an orphanage in Mexico.

Vaughn and his friends sat at a private booth and enjoyed the bar's signature margaritas. He looked like he was enjoying himself as he mingled with fellow partygoers.

True to his reputation, Vaughn was dressed in his signature jeans and plaid button-up. At first, the actor and his crew kept it low-key in their booth by the doorway, but by the end of the night, he was the center of attention as girls were crowding around him.

Eventually, Vaughn turned his attention to one girl with a short blond ponytail and a cowboy hat. She was in her 20s, petite and wore dark eyeliner. According to an eyewitness, "Vince seemed interested in her. He wanted her to stick around." Apparently, he was very interested, because the two left the party together.

—Reporting by Whitney English and Jeanifer Hwang